3 edition of Membrane microdomain regulation of neuron signaling found in the catalog.
Membrane microdomain regulation of neuron signaling
Wallace, Ron Dr.
Includes bibliographical references (p. -81) and index.
|LC Classifications||QP363 .W35 2008|
|The Physical Object|
|Pagination||x, 93 p. :|
|Number of Pages||93|
|LC Control Number||2007051509|
Synaptic signaling is a special case of paracrine signaling (for chemical synapses) or juxtacrine signaling (for electrical synapses) between neurons and target cells. Signaling molecules interact with a target cell as a ligand to cell surface receptors, and/or by entering into the cell through its membrane or endocytosis for intracrine signaling. The plasma membrane is a highly compartmentalised organelle containing specialised lipid microdomains or lipid rafts that enable the spatial regulation of signal transduction. Lipid microdomains are enriched in sphingolipids and cholesterol that are arranged in a highly ordered state.
GM3-associated membrane microdomain of lipid raft formation is crucial for the relevant organization stereocilia in auditory hair cells . GM3 is the dominant cochlear GSL. In postnatal periods, GM3 level is increased with GlcCer, sulatides of SM3 and SM4, GM1, GD1a, GD3, GD1b, and GT1b. Experience-dependent remodeling of the postsynaptic density (PSD) is critical for synapse formation and plasticity in the mammalian brain. Here, in cultured rat hippocampal neurons, I .
cells. Cell signaling (or signal transduction) involves: • Detection of the stimulus (in most cases a molecule secreted by another cell) on the surface of the plasma membrane. • Transfer of the signal to the cytoplasmic side. • Transmission of the signal to effector molecules and down a signaling pathway where every protein typically changes. Transmission of a signal between neurons is generally carried by a chemical called a neurotransmitter. Transmission of a signal within a neuron (from dendrite to axon terminal) is carried by a brief reversal of the resting membrane potential called an action potential. When neurotransmitter molecules bind to receptors located on a neuron’s.
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Contents Preface vii Chapter I Introduction 1 Chapter II Membrane Studies: The Problem of Order 5 Chapter III Membrane Microdomain Regulation of Neuron Signaling 27 Chapter IV Membrane Microdomains and Neural Impulse Propagation: Field Effects in Cytoskeleton Corrals 39 Chapter V Toward Membrane Molecular Machines: Implications for the Study of Neural Disease Membrane studies: the problem of order --Membrane microdomain regulation of neuron signaling --Membrane microdomains and neural impulse propagation: field effects in cytoskeleton corrals --Toward membrane molecular machines: implications for the study of neural disease.
Responsibility: Ron Wallace. More information: Table of contents. Membrane Microdomain Regulation of Neuron Signaling This chapter presents a model of membrane microdomain regulation of neuron signaling. It is based on laboratory investigations of natural and artificial membranes as well as computer-simulation studies conducted by Harry Price in collaboration with the author (Price and Wallace, ; ).
Membrane studies: the problem of order --Membrane microdomain regulation of neuron signaling --Membrane microdomains and neural impulse propagation: field effects in cytoskeleton corrals --Toward membrane molecular machines: implications for the study.
Similar RhoGTPase regulation of microdomain polarization occurs during Fas/CD95 DISC formation in lymphocytes and may represent a mechanism that is conserved across the immune and nervous systems for death signal transduction.
As in Fas DISC death signaling, disruption of aggregation and polarization of this module in neurons, mediated through. Immunoglobulin E (IgE) signaling is the first convincingly demonstrated lipid rafts involving signaling process. Evidence for this fact includes decreased solubility of Fc-epsilon receptors (FcεR) in Triton X from steady state to crosslinking state, formation of patches large enough to be visualized by fluorescence microscopy from gangliosides and GPI-anchored proteins, abolition of IgE.
The first is that the neural membrane microdomain, and not the neuron, is the fundamental computational unit in the brain. The second is that artificial models of microdomain regulation of ion-channel activity may be useful in understanding the molecular basis of neural diseases.
The first possibility partly depends on one's definition of a. Throughout much of the history of biology, the cell membrane was functionally defined as a semi-permeable barrier separating aqueous compartments, and an anchoring site for proteins.
Little attention was devoted to its possible regulatory role in intracellular molecular processes and neuron electrical signaling.
This article reviews the history of membrane studies and the current state of the art. This signaling complex is formed well before neurons commit to die, consis tent with an early role in death signal transduction.
Neurons from Ngb‐overexpressing transgenic (Ngb‐Tg) mice do not undergo microdomain polarization or mitochondrial aggregation in response to. Neuron-oligodendroglia signaling is essential for myelination and circuit function. • Neuronal activity modulates intracellular calcium in oligodendroglia.
• Intracellular calcium affects cytoskeleton, gene expression, and metabolic support. • Neuronal activity-dependent signaling drives remyelination and disease recovery. ) and index. Contents: Membrane studies: the problem of order -- Membrane microdomain regulation of neuron signaling -- Membrane microdomains and neural impulse propagation: field effects in cytoskeleton corrals -- Toward membrane molecular machines: implications for the study of neural disease.
NLM ID: [Book]. Neural Membrane Signaling Platforms. Membrane Microdomain Regulation of Neuron Signaling. Book. Jan ; Neuromolecular Computing in Brain Evolution: Models and Methods. Trafficking, an additional mechanism by which CAVs regulate membrane-initiated signaling, refers to the ability of CAVs to move membrane receptors and intracellular signaling molecules to and from the plasma membrane [30–38].Notably, this mechanism of action also allows for CAV-mediated bidirectional regulation of signal transduction.
We propose that microdomain switching is a mechanism of cholesterol- and activity-dependent regulation of APP processing in neurons. Introduction Increasing evidence indicates that amyloid-β peptide (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD.
5. Microdomain-based Molecular Machines and Artificial Intelligence. This review has evaluated a rapidly growing body of evidence suggesting that neural-membrane microdomains may function as dynamic scaffolds which co-localize signal units, thereby modulating neuron. plane of the membrane during AP propagation may transiently alter microdomain physical properties in a manner that could modulate ion - channel activity, thereb y altering neuron signaling [50,51].
The sophistication of PLC signaling is best illustrated by the phototransduction cascade in the fruitfly Drosophila 3, 4, PLCβ-coupled mechanism represents the fastest G q-protein-signaling pathway known: the absorption of a single photon by rhodopsin is translated into a physiological response (a depolarization) in just 20 eless, phototransduction in flies is a.
1. Introduction. Membrane receptors, involved in downstream signal transduction are generally transmembrane proteins. Their assembly and arrangement in the membrane determine how they interact with their ligands through the extracellular domains and generate signaling cascades through the cytoplasmic conformation of transmembrane domain of a receptor regulates.
Modulation of membrane properties as a mechanism of nitric oxide signaling in neurons. Book. Membrane Microdomain Regulation of Neuron Signaling. January Ron Wallace; Read more. Plasticity is a remarkable feature of the brain, allowing neuronal structure and function to accommodate to patterns of electrical activity.
One component of these long-term changes is the activity-driven induction of new gene expression, which is required for both the long-lasting long-term potentiation of synaptic transmission associated with learning and memory, and the activitydependent.
Lipid microdomains (“rafts”) are dynamic, nanoscale regions of the plasma membrane enriched in cholesterol and glycosphingolipids, that possess distinctive physicochemical properties including higher order than the surrounding membrane.
Lipid microdomain integrity is thought to affect neurotransmitter signaling by regulating membrane-bound.Membrane microdomains, often referred to as lipid rafts, are specific subdomains in cellular membranes that are enriched in cholesterol and sphingolipids containing saturated acyl chains (Brown and London, ; Simons and Toomre, ).These microdomains arise due to interactions of cholesterol with saturated acyl chains that result in tight packing of these lipids in comparison to.How the structure of a neuron allows it to receive and transmit information.
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